Assay Detail
Binding
CHEMBL754264
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Inhibitory activity against hepatitis C virus (HCV) NS3/NS4A serine protease
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepacivirus hominis |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Hepatitis C virus serine protease, NS3/NS4A (CHEMBL2095231) ↗| Type | PROTEIN COMPLEX |
| Organism | Hepatitis C virus |
Publication
Evolution, synthesis and SAR of tripeptide alpha-ketoacid inhibitors of the hepatitis C virus NS3/NS4A serine protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 9.23 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL349186 | — | — | 1 | 11.00 |
| CHEMBL160002 | — | — | 1 | 9.30 |
| CHEMBL421233 | — | — | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL349186 | — | Ki | = | 0.01 | nM | 11.00 |
| CHEMBL160002 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL421233 | — | Ki | = | 40.0 | nM | 7.40 |