Assay Detail
Functional
CHEMBL754304
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxic activity against cellular metabolic activity of Ovary SKOV3 tumor cell line using XTT proliferation assay after incubation with the compound for 48 h
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-OV-3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.32 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.00 |
| CHEMBL116173 | — | — | 1 | 7.30 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.30 |
| CHEMBL112192 | — | — | 1 | 7.22 |
| CHEMBL9514 | NOCODAZOLE | 2.0 | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL116173 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL107 | COLCHICINE | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL112192 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL9514 | NOCODAZOLE | IC50 | = | 170.0 | nM | 6.77 |