Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL754353

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Neurotensin receptor type 1 (CHEMBL4123)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

In vitro analysis of stable, receptor-selective neurotensin[8-13] analogues.
Kokko KP, Hadden MK, Orwig KS, Mazella J, Dix TA.
J Med Chem (2003) 46 : 4141 -4148
PubMed 12954066 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 9.21 9.62

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL133340 1 9.62
CHEMBL336836 1 9.60
CHEMBL133850 1 9.55
CHEMBL430910 1 9.52
CHEMBL434227 1 9.52
CHEMBL342252 1 9.52
CHEMBL132524 1 9.52
CHEMBL129953 1 9.47
CHEMBL337260 1 9.47
CHEMBL133378 1 9.44
CHEMBL337644 1 9.42
CHEMBL132409 1 9.40
CHEMBL439494 1 9.40
CHEMBL132507 1 9.40
CHEMBL132794 1 9.29
CHEMBL133849 1 9.28
CHEMBL339139 1 9.23
CHEMBL337721 1 8.92
CHEMBL133798 1 8.80
CHEMBL335846 1 8.24
CHEMBL435199 1 6.88

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL133340 IC50 = 0.24 nM 9.62
CHEMBL336836 IC50 = 0.25 nM 9.60
CHEMBL133850 IC50 = 0.28 nM 9.55
CHEMBL430910 IC50 = 0.3 nM 9.52
CHEMBL434227 IC50 = 0.3 nM 9.52
CHEMBL342252 IC50 = 0.3 nM 9.52
CHEMBL132524 IC50 = 0.3 nM 9.52
CHEMBL129953 IC50 = 0.34 nM 9.47
CHEMBL337260 IC50 = 0.34 nM 9.47
CHEMBL133378 IC50 = 0.36 nM 9.44
CHEMBL337644 IC50 = 0.38 nM 9.42
CHEMBL132409 IC50 = 0.4 nM 9.40
CHEMBL439494 IC50 = 0.4 nM 9.40
CHEMBL132507 IC50 = 0.4 nM 9.40
CHEMBL132794 IC50 = 0.51 nM 9.29
CHEMBL133849 IC50 = 0.52 nM 9.28
CHEMBL339139 IC50 = 0.59 nM 9.23
CHEMBL337721 IC50 = 1.2 nM 8.92
CHEMBL133798 IC50 = 1.6 nM 8.80
CHEMBL335846 IC50 = 5.71 nM 8.24
CHEMBL435199 IC50 = 133.0 nM 6.88