Assay Detail
Binding
CHEMBL754362
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Inhibitory activity against neutral endopeptidase (NEP) from human blood serum
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Computer-aided selection of potential antihypertensive compounds with dual mechanism of action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.47 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL479579 | PHOSPHORAMIDON | — | 1 | 7.00 |
| CHEMBL322069 | — | — | 1 | 4.70 |
| CHEMBL326801 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL479579 | PHOSPHORAMIDON | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL322069 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL326801 | — | IC50 | = | 20000.0 | nM | 4.70 |