Assay Detail
Binding
CHEMBL754363
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Inhibition of neutral endopeptidase 24.11(NEP)
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Potent non-peptidic dual inhibitors of endothelin-converting enzyme and neutral endopeptidase 24.11
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.51 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL268473 | — | — | 1 | 9.22 |
| CHEMBL276690 | — | — | 1 | 9.15 |
| CHEMBL276872 | — | — | 1 | 9.13 |
| CHEMBL290698 | — | — | 1 | 9.05 |
| CHEMBL268761 | — | — | 1 | 8.84 |
| CHEMBL273489 | — | — | 1 | 8.60 |
| CHEMBL10251 | — | — | 1 | 8.32 |
| CHEMBL10247 | THIORPHAN | -1.0 | 1 | 8.32 |
| CHEMBL415967 | CGS-314447 | — | 1 | 8.16 |
| CHEMBL9963 | — | — | 1 | 8.06 |
| CHEMBL418704 | — | — | 1 | 7.77 |
| CHEMBL479579 | PHOSPHORAMIDON | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL268473 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL276690 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL276872 | — | IC50 | = | 0.74 | nM | 9.13 |
| CHEMBL290698 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL268761 | — | IC50 | = | 1.46 | nM | 8.84 |
| CHEMBL273489 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL10251 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL10247 | THIORPHAN | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL415967 | CGS-314447 | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL9963 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL418704 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL479579 | PHOSPHORAMIDON | IC50 | = | 30.0 | nM | 7.52 |