Assay Detail
Binding
CHEMBL754401
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Binding affinity (Ki) was determined towards Opioid receptors by competition with [3H]diprenorphine in rat whole brain membrane preparation
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
N-(3-[18F]fluoropropyl)-N-nordiprenorphine: synthesis and characterization of a new agent for imaging opioid receptors with positron emission tomography.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.28 | 9.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281786 | DIPRENORPHINE | 2.0 | 1 | 9.66 |
| CHEMBL3350996 | — | — | 1 | 8.62 |
| CHEMBL3350998 | — | — | 1 | 8.57 |
| CHEMBL3350997 | — | — | 1 | 8.23 |
| CHEMBL3350993 | — | — | 1 | 8.07 |
| CHEMBL3350995 | — | — | 1 | 7.97 |
| CHEMBL3350683 | — | — | 1 | 7.97 |
| CHEMBL3350684 | — | — | 1 | 7.72 |
| CHEMBL3350994 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281786 | DIPRENORPHINE | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL3350996 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL3350998 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL3350997 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL3350993 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL3350995 | — | Ki | = | 10.7 | nM | 7.97 |
| CHEMBL3350683 | — | Ki | = | 10.8 | nM | 7.97 |
| CHEMBL3350684 | — | Ki | = | 18.9 | nM | 7.72 |
| CHEMBL3350994 | — | Ki | = | 20.2 | nM | 7.70 |