Assay Detail
Binding
CHEMBL754435
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]naltrindole binding to opioid receptor delta 1 of Chinese hamster ovary membrane
14
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cricetulus griseus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2-aminothiazole-derived opioids. Bioisosteric replacement of phenols.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 7.32 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL59092 | — | — | 1 | 8.96 |
| CHEMBL49269 | CYCLORPHAN | — | 1 | 8.72 |
| CHEMBL592 | LEVORPHANOL | 4.0 | 1 | 8.38 |
| CHEMBL301160 | BUTORPHAN | — | 1 | 8.23 |
| CHEMBL242756 | — | — | 1 | 7.54 |
| CHEMBL294168 | — | — | 1 | 7.50 |
| CHEMBL301701 | — | — | 1 | 7.03 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 6.85 |
| CHEMBL1766021 | — | — | 2 | 6.72 |
| CHEMBL390866 | — | — | 1 | 6.64 |
| CHEMBL48241 | — | — | 1 | 6.58 |
| CHEMBL56356 | — | — | 1 | 6.03 |
| CHEMBL299713 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL59092 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL49269 | CYCLORPHAN | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL592 | LEVORPHANOL | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL301160 | BUTORPHAN | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL242756 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL294168 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL301701 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL70 | MORPHINE | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL1766021 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL390866 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL48241 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL56356 | — | Ki | = | 940.0 | nM | 6.03 |
| CHEMBL1766021 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL299713 | — | Ki | > | 10000.0 | nM | - |