Assay Detail
Functional
CHEMBL754454
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity against recombinant human P2X purinoceptor 7 (P2X7)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Purine and pyrimidine (P2) receptors as drug targets.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.26 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL28324 | — | — | 1 | 7.47 |
| CHEMBL339386 | — | — | 1 | 4.28 |
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 4.04 |
| CHEMBL132722 | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER | — | 1 | - |
| CHEMBL14249 | ADENOSINE TRIPHOSPHATE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL28324 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL339386 | — | EC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL265502 | SURAMIN | EC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL132722 | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER | EC50 | > | 100000.0 | nM | - |
| CHEMBL14249 | ADENOSINE TRIPHOSPHATE | EC50 | = | 780000.0 | nM | - |