Assay Detail
Binding
CHEMBL754455
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Inhibitory concentration was evaluated against P2X purinoceptor 7
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis of conformationally constrained analogues of KN62, a potent antagonist of the P2X7-receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.19 | 7.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL28324 | — | — | 1 | 7.87 |
| CHEMBL350311 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL28324 | — | IC50 | = | 13.4 | nM | 7.87 |
| CHEMBL350311 | — | IC50 | = | 316.0 | nM | 6.50 |