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Assay Detail

CHEMBL754467

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to Opioid receptor delta 1 using [3H]DPDPE as a radioligand in guinea pig
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cavia porcellus
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Delta-type opioid receptor (CHEMBL236)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Selective delta-opioid receptor ligands: potential PET ligands based on naltrindole.
Clayson J, Jales A, Tyacke RJ, Hudson AL, Nutt DJ, Lewis JW, Husbands SM.
Bioorg Med Chem Lett (2001) 11 : 939 -943
PubMed 11294396 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 19 8.70 9.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL567175 NALTRINDOLE 1 9.82
CHEMBL368522 1 9.62
CHEMBL367497 1 9.59
CHEMBL368421 1 9.40
CHEMBL172493 1 9.36
CHEMBL477154 1 9.31
CHEMBL367962 1 9.26
CHEMBL173874 1 9.11
CHEMBL170399 1 9.09
CHEMBL176537 1 9.05
CHEMBL172529 1 8.75
CHEMBL368600 1 8.62
CHEMBL173749 1 8.57
CHEMBL435898 1 8.19
CHEMBL353930 1 8.00
CHEMBL173319 1 7.89
CHEMBL367290 1 7.72
CHEMBL174263 1 7.56
CHEMBL177194 1 6.42

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL567175 NALTRINDOLE Ki = 0.15 nM 9.82
CHEMBL368522 Ki = 0.24 nM 9.62
CHEMBL367497 Ki = 0.26 nM 9.59
CHEMBL368421 Ki = 0.4 nM 9.40
CHEMBL172493 Ki = 0.44 nM 9.36
CHEMBL477154 Ki = 0.49 nM 9.31
CHEMBL367962 Ki = 0.55 nM 9.26
CHEMBL173874 Ki = 0.77 nM 9.11
CHEMBL170399 Ki = 0.82 nM 9.09
CHEMBL176537 Ki = 0.89 nM 9.05
CHEMBL172529 Ki = 1.78 nM 8.75
CHEMBL368600 Ki = 2.41 nM 8.62
CHEMBL173749 Ki = 2.66 nM 8.57
CHEMBL435898 Ki = 6.44 nM 8.19
CHEMBL353930 Ki = 10.1 nM 8.00
CHEMBL173319 Ki = 12.9 nM 7.89
CHEMBL367290 Ki = 19.0 nM 7.72
CHEMBL174263 Ki = 27.4 nM 7.56
CHEMBL177194 Ki = 381.0 nM 6.42