Assay Detail
Binding
CHEMBL754508
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Affinity for human Opioid receptor like 1 (ORL-1) expressed in HEK293 cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel, potent ORL-1 receptor agonist peptides containing alpha-Helix-promoting conformational constraints.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 8.80 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL414542 | — | — | 1 | 10.22 |
| CHEMBL266191 | — | — | 1 | 10.10 |
| CHEMBL408356 | — | — | 1 | 9.85 |
| CHEMBL415845 | — | — | 1 | 9.70 |
| CHEMBL264084 | — | — | 1 | 9.57 |
| CHEMBL396460 | NOCICEPTIN | — | 1 | 9.35 |
| CHEMBL410979 | — | — | 1 | 9.33 |
| CHEMBL438537 | — | — | 1 | 9.14 |
| CHEMBL415584 | — | — | 1 | 9.00 |
| CHEMBL436732 | — | — | 1 | 8.28 |
| CHEMBL405212 | — | — | 1 | 7.98 |
| CHEMBL414543 | — | — | 1 | 7.28 |
| CHEMBL427617 | — | — | 1 | 7.02 |
| CHEMBL414541 | — | — | 1 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL414542 | — | EC50 | = | 0.06 | nM | 10.22 |
| CHEMBL266191 | — | EC50 | = | 0.08 | nM | 10.10 |
| CHEMBL408356 | — | EC50 | = | 0.14 | nM | 9.85 |
| CHEMBL415845 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL264084 | — | EC50 | = | 0.27 | nM | 9.57 |
| CHEMBL396460 | NOCICEPTIN | EC50 | = | 0.45 | nM | 9.35 |
| CHEMBL410979 | — | EC50 | = | 0.47 | nM | 9.33 |
| CHEMBL438537 | — | EC50 | = | 0.73 | nM | 9.14 |
| CHEMBL415584 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL436732 | — | EC50 | = | 5.3 | nM | 8.28 |
| CHEMBL405212 | — | EC50 | = | 10.5 | nM | 7.98 |
| CHEMBL414543 | — | EC50 | = | 52.0 | nM | 7.28 |
| CHEMBL427617 | — | EC50 | = | 96.0 | nM | 7.02 |
| CHEMBL414541 | — | EC50 | = | 407.0 | nM | 6.39 |