Assay Detail
Functional
CHEMBL754546
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Growth inhibition (IC50) against Plasmodium falciparum wild-type TM4/8.2
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Development of a lead inhibitor for the A16V+S108T mutant of dihydrofolate reductase from the cycloguanil-resistant strain (T9/94) of Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.41 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6741 | — | — | 1 | 7.51 |
| CHEMBL93153 | — | — | 1 | 7.46 |
| CHEMBL92047 | — | — | 1 | 7.40 |
| CHEMBL7130 | — | — | 1 | 7.22 |
| CHEMBL7004 | — | — | 1 | 7.19 |
| CHEMBL93748 | — | — | 1 | 6.88 |
| CHEMBL90461 | — | — | 1 | 6.88 |
| CHEMBL443013 | — | — | 1 | 6.78 |
| CHEMBL89959 | — | — | 1 | 6.56 |
| CHEMBL7005 | — | — | 1 | 6.53 |
| CHEMBL92182 | — | — | 1 | 6.33 |
| CHEMBL6742 | — | — | 1 | 6.26 |
| CHEMBL94281 | — | — | 1 | 6.20 |
| CHEMBL264392 | — | — | 1 | 5.54 |
| CHEMBL433204 | — | — | 1 | 5.54 |
| CHEMBL90358 | — | — | 1 | 5.08 |
| CHEMBL93001 | — | — | 1 | 5.01 |
| CHEMBL92846 | — | — | 1 | 4.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6741 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL93153 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL92047 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL7130 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL7004 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL93748 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL90461 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL443013 | — | IC50 | = | 167.0 | nM | 6.78 |
| CHEMBL89959 | — | IC50 | = | 273.0 | nM | 6.56 |
| CHEMBL7005 | — | IC50 | = | 294.0 | nM | 6.53 |
| CHEMBL92182 | — | IC50 | = | 462.0 | nM | 6.33 |
| CHEMBL6742 | — | IC50 | = | 546.0 | nM | 6.26 |
| CHEMBL94281 | — | IC50 | = | 638.0 | nM | 6.20 |
| CHEMBL264392 | — | IC50 | = | 2908.0 | nM | 5.54 |
| CHEMBL433204 | — | IC50 | = | 2908.0 | nM | 5.54 |
| CHEMBL90358 | — | IC50 | = | 8223.0 | nM | 5.08 |
| CHEMBL93001 | — | IC50 | = | 9661.0 | nM | 5.01 |
| CHEMBL92846 | — | IC50 | = | 11632.0 | nM | 4.93 |