Assay Detail
Functional
CHEMBL754549
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Growth inhibition (IC50) against Plasmodium falciparum wild-type TM4/8.2
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Development of a lead inhibitor for the A16V+S108T mutant of dihydrofolate reductase from the cycloguanil-resistant strain (T9/94) of Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.99 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL93889 | — | — | 1 | 7.57 |
| CHEMBL93974 | — | — | 1 | 7.40 |
| CHEMBL93893 | — | — | 1 | 7.33 |
| CHEMBL93888 | — | — | 1 | 7.20 |
| CHEMBL90703 | — | — | 1 | 7.19 |
| CHEMBL90292 | — | — | 1 | 6.96 |
| CHEMBL91345 | — | — | 1 | 6.87 |
| CHEMBL329687 | — | — | 1 | 6.34 |
| CHEMBL90018 | — | — | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL93889 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL93974 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL93893 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL93888 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL90703 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL90292 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL91345 | — | IC50 | = | 136.0 | nM | 6.87 |
| CHEMBL329687 | — | IC50 | = | 455.0 | nM | 6.34 |
| CHEMBL90018 | — | IC50 | = | 952.0 | nM | 6.02 |