Assay Detail
Binding
CHEMBL754586
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Affinity for human Opioid receptor like 1 (ORL-1) expressed in HEK293 cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel, potent ORL-1 receptor agonist peptides containing alpha-Helix-promoting conformational constraints.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 9.40 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL415845 | — | — | 1 | 10.70 |
| CHEMBL266191 | — | — | 1 | 10.30 |
| CHEMBL414542 | — | — | 1 | 10.30 |
| CHEMBL438537 | — | — | 1 | 10.22 |
| CHEMBL408356 | — | — | 1 | 10.10 |
| CHEMBL264084 | — | — | 1 | 10.00 |
| CHEMBL410979 | — | — | 1 | 9.82 |
| CHEMBL396460 | NOCICEPTIN | — | 1 | 9.52 |
| CHEMBL415584 | — | — | 1 | 9.32 |
| CHEMBL436732 | — | — | 1 | 8.96 |
| CHEMBL405212 | — | — | 1 | 8.66 |
| CHEMBL414543 | — | — | 1 | 8.17 |
| CHEMBL427617 | — | — | 1 | 7.82 |
| CHEMBL414541 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL415845 | — | Ki | = | 0.02 | nM | 10.70 |
| CHEMBL266191 | — | Ki | = | 0.05 | nM | 10.30 |
| CHEMBL414542 | — | Ki | = | 0.05 | nM | 10.30 |
| CHEMBL438537 | — | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL408356 | — | Ki | = | 0.08 | nM | 10.10 |
| CHEMBL264084 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL410979 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL396460 | NOCICEPTIN | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL415584 | — | Ki | = | 0.48 | nM | 9.32 |
| CHEMBL436732 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL405212 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL414543 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL427617 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL414541 | — | Ki | = | 20.0 | nM | 7.70 |