Assay Detail
Binding
CHEMBL754588
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive binding affinity against transfected HEK293 cells expressing human Opioid receptor like 1
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
High-affinity, non-peptide agonists for the ORL1 (orphanin FQ/nociceptin) receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 8.21 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281274 | — | — | 1 | 9.28 |
| CHEMBL280827 | — | — | 1 | 8.85 |
| CHEMBL28172 | — | — | 1 | 8.60 |
| CHEMBL283910 | — | — | 1 | 8.55 |
| CHEMBL27699 | — | — | 1 | 8.54 |
| CHEMBL27729 | — | — | 1 | 8.48 |
| CHEMBL283480 | — | — | 1 | 8.25 |
| CHEMBL447779 | — | — | 1 | 8.24 |
| CHEMBL26999 | — | — | 1 | 8.20 |
| CHEMBL283265 | — | — | 1 | 8.17 |
| CHEMBL283617 | — | — | 1 | 8.14 |
| CHEMBL26987 | — | — | 1 | 8.14 |
| CHEMBL285377 | — | — | 1 | 7.82 |
| CHEMBL26483 | — | — | 1 | 7.82 |
| CHEMBL418020 | — | — | 1 | 7.68 |
| CHEMBL27093 | — | — | 1 | 6.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281274 | — | Ki | = | 0.52 | nM | 9.28 |
| CHEMBL280827 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL28172 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL283910 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL27699 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL27729 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL283480 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL447779 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL26999 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL283265 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL283617 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL26987 | — | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL285377 | — | Ki | = | 15.3 | nM | 7.82 |
| CHEMBL26483 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL418020 | — | Ki | = | 20.7 | nM | 7.68 |
| CHEMBL27093 | — | Ki | = | 218.0 | nM | 6.66 |