Assay Detail
Binding
CHEMBL754635
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The opioid receptor affinity(Ki) was evaluated by competition with [3H]DSLET (delta 2) on guinea pig brain membranes
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
7'-Substituted amino acid conjugates of naltrindole. Hydrophilic groups as determinants of selective antagonism of delta 1 opioid receptor-mediated antinociception in mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 10.04 | 10.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL132897 | — | — | 1 | 10.82 |
| CHEMBL132420 | — | — | 1 | 10.80 |
| CHEMBL334715 | — | — | 1 | 10.08 |
| CHEMBL334970 | — | — | 1 | 9.39 |
| CHEMBL335936 | — | — | 1 | 9.12 |
| CHEMBL422258 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL132897 | — | Ki | = | 0.015 | nM | 10.82 |
| CHEMBL132420 | — | Ki | = | 0.016 | nM | 10.80 |
| CHEMBL334715 | — | Ki | = | 0.083 | nM | 10.08 |
| CHEMBL334970 | — | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL335936 | — | Ki | = | 0.75 | nM | 9.12 |
| CHEMBL422258 | — | Ki | = | 0.00066 | nM | - |