Assay Detail
Functional
CHEMBL754702
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Antiproliferative activity against P388 tumor cell line
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | P388/ADR |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.29 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL238071 | VINDESINE | 3.0 | 1 | 8.00 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.40 |
| CHEMBL9514 | NOCODAZOLE | 2.0 | 1 | 7.16 |
| CHEMBL112192 | — | — | 1 | 7.10 |
| CHEMBL116173 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL238071 | VINDESINE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL9514 | NOCODAZOLE | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL112192 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL116173 | — | IC50 | = | 160.0 | nM | 6.80 |