Assay Detail
Binding
CHEMBL754752
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Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes
40
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Nucleosides and nucleotides. 200. Reinvestigation of 5'-N-ethylcarboxamidoadenosine derivatives: structure-activity relationships for P(3) purinoceptor-like proteins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 40 | 7.21 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL609487 | — | — | 1 | 8.00 |
| CHEMBL2113492 | — | — | 1 | 7.92 |
| CHEMBL2092859 | — | — | 1 | 7.89 |
| CHEMBL609186 | — | — | 1 | 7.77 |
| CHEMBL2113489 | — | — | 1 | 7.75 |
| CHEMBL607719 | — | — | 1 | 7.72 |
| CHEMBL608888 | — | — | 1 | 7.70 |
| CHEMBL1791423 | — | — | 1 | 7.70 |
| CHEMBL608293 | — | — | 1 | 7.70 |
| CHEMBL608296 | — | — | 1 | 7.68 |
| CHEMBL609773 | — | — | 1 | 7.66 |
| CHEMBL608893 | — | — | 1 | 7.64 |
| CHEMBL612154 | — | — | 1 | 7.57 |
| CHEMBL464859 | NECA | — | 2 | 7.57 |
| CHEMBL609776 | — | — | 1 | 7.54 |
| CHEMBL1235128 | — | — | 1 | 7.51 |
| CHEMBL609769 | — | — | 1 | 7.51 |
| CHEMBL608595 | — | — | 1 | 7.39 |
| CHEMBL607717 | — | — | 1 | 7.38 |
| CHEMBL609775 | — | — | 1 | 7.34 |
| CHEMBL2070508 | — | — | 1 | 7.31 |
| CHEMBL519809 | — | — | 1 | 7.29 |
| CHEMBL2092773 | — | — | 1 | 7.25 |
| CHEMBL2113434 | — | — | 1 | 7.24 |
| CHEMBL605866 | — | — | 1 | 7.19 |
| CHEMBL608587 | — | — | 1 | 7.17 |
| CHEMBL608591 | — | — | 1 | 7.16 |
| CHEMBL2070507 | — | — | 1 | 7.06 |
| CHEMBL261482 | — | — | 1 | 7.02 |
| CHEMBL609768 | — | — | 1 | 6.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL609487 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL2113492 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL2092859 | — | Ki | = | 12.9 | nM | 7.89 |
| CHEMBL609186 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL2113489 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL607719 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL608888 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL608293 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL1791423 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL608296 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL609773 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL608893 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL612154 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL464859 | NECA | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL609776 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL1235128 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL609769 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL464859 | NECA | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL608595 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL607717 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL609775 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL2070508 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL519809 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL2092773 | — | Ki | = | 55.6 | nM | 7.25 |
| CHEMBL2113434 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL605866 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL608587 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL608591 | — | Ki | = | 69.5 | nM | 7.16 |
| CHEMBL2070507 | — | Ki | = | 88.0 | nM | 7.06 |
| CHEMBL261482 | — | Ki | = | 96.0 | nM | 7.02 |
| CHEMBL609768 | — | Ki | = | 123.0 | nM | 6.91 |
| CHEMBL608003 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL609485 | — | Ki | = | 163.0 | nM | 6.79 |
| CHEMBL129903 | — | Ki | = | 167.0 | nM | 6.78 |
| CHEMBL608895 | — | Ki | = | 198.0 | nM | 6.70 |
| CHEMBL608596 | — | Ki | = | 640.0 | nM | 6.19 |
| CHEMBL609179 | — | Ki | = | 833.0 | nM | 6.08 |
| CHEMBL608000 | — | Ki | = | 1040.0 | nM | 5.98 |
| CHEMBL609774 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL2113436 | — | Ki | = | 6850.0 | nM | 5.16 |