Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL754783

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity for Neurotensin Receptor
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mus musculus
Confidence 9 — Direct single protein target
Curated By Expert

Target

Neurotensin receptor type 1 (CHEMBL3570)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Reduced amide bond neurotensin 813 mimetics with potent in vivo activity
Wustrow D, Davis M, Akunne H, Corbin A, Wiley J, Wise L, Heffner T
Bioorg Med Chem Lett (1995) 5 : 997 -1002
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 13 8.48 10.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL427604 1 10.22
CHEMBL6716 1 10.00
CHEMBL1793865 1 9.82
CHEMBL6508 1 9.40
CHEMBL342252 1 9.28
CHEMBL269601 1 8.95
CHEMBL6505 1 8.42
CHEMBL267459 1 7.77
CHEMBL427956 1 7.77
CHEMBL265671 1 7.57
CHEMBL6562 1 7.51
CHEMBL380726 1 7.22
CHEMBL268600 1 6.36

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL427604 Ki = 0.06 nM 10.22
CHEMBL6716 Ki = 0.1 nM 10.00
CHEMBL1793865 Ki = 0.15 nM 9.82
CHEMBL6508 Ki = 0.4 nM 9.40
CHEMBL342252 Ki = 0.52 nM 9.28
CHEMBL269601 Ki = 1.13 nM 8.95
CHEMBL6505 Ki = 3.8 nM 8.42
CHEMBL267459 Ki = 17.1 nM 7.77
CHEMBL427956 Ki = 17.0 nM 7.77
CHEMBL265671 Ki = 27.0 nM 7.57
CHEMBL6562 Ki = 31.2 nM 7.51
CHEMBL380726 Ki = 60.0 nM 7.22
CHEMBL268600 Ki = 437.0 nM 6.36