Assay Detail
Binding
CHEMBL754785
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Compound was evaluated for the binding affinity against human neurotensin receptor (hNTR)-1 expressed in CHO cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis of neurotensin(9-13) analogues exhibiting enhanced human neurotensin receptor binding affinities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.07 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL138970 | — | — | 1 | 8.89 |
| CHEMBL141872 | — | — | 1 | 8.41 |
| CHEMBL139727 | — | — | 1 | 8.06 |
| CHEMBL344020 | — | — | 1 | 8.03 |
| CHEMBL343970 | — | — | 1 | 7.83 |
| CHEMBL48981 | — | — | 1 | 7.72 |
| CHEMBL141910 | — | — | 1 | 7.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL138970 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL141872 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL139727 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL344020 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL343970 | — | IC50 | = | 14.7 | nM | 7.83 |
| CHEMBL48981 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL141910 | — | IC50 | = | 28.0 | nM | 7.55 |