Assay Detail
Binding
CHEMBL754790
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Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HT-29 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Novel bioactive and stable neurotensin peptide analogues capable of delivering radiopharmaceuticals and molecular beacons to tumors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 8.55 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL407196 | NEUROTENSIN | — | 1 | 9.70 |
| CHEMBL408127 | — | — | 1 | 9.52 |
| CHEMBL408381 | — | — | 1 | 9.52 |
| CHEMBL2370478 | — | — | 1 | 9.40 |
| CHEMBL409477 | — | — | 1 | 9.40 |
| CHEMBL408638 | — | — | 1 | 9.40 |
| CHEMBL404942 | — | — | 1 | 9.40 |
| CHEMBL3142915 | — | — | 1 | 9.30 |
| CHEMBL2369628 | — | — | 1 | 9.30 |
| CHEMBL386387 | — | — | 1 | 9.22 |
| CHEMBL2369133 | — | — | 1 | 9.22 |
| CHEMBL3706654 | — | — | 1 | 9.22 |
| CHEMBL3706655 | — | — | 1 | 8.92 |
| CHEMBL437707 | — | — | 1 | 8.82 |
| CHEMBL424896 | — | — | 1 | 8.60 |
| CHEMBL3706653 | — | — | 1 | 8.47 |
| CHEMBL413192 | — | — | 1 | 8.20 |
| CHEMBL2369627 | — | — | 1 | 7.99 |
| CHEMBL405160 | — | — | 1 | 7.94 |
| CHEMBL407187 | — | — | 1 | 7.93 |
| CHEMBL405804 | — | — | 1 | 7.66 |
| CHEMBL2369629 | — | — | 1 | 7.66 |
| CHEMBL2370477 | — | — | 1 | 7.61 |
| CHEMBL413010 | — | — | 1 | 7.37 |
| CHEMBL2370480 | — | — | 1 | 7.22 |
| CHEMBL2370479 | — | — | 1 | 6.97 |
| CHEMBL410289 | — | — | 1 | 6.95 |
| CHEMBL436717 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL407196 | NEUROTENSIN | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL408127 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL408381 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL2370478 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL409477 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL408638 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL404942 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL3142915 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL2369628 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL386387 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL2369133 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL3706654 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL3706655 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL437707 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL424896 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL3706653 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL413192 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL2369627 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL405160 | — | IC50 | = | 11.5 | nM | 7.94 |
| CHEMBL407187 | — | IC50 | = | 11.87 | nM | 7.93 |
| CHEMBL405804 | — | IC50 | = | 21.7 | nM | 7.66 |
| CHEMBL2369629 | — | IC50 | = | 22.1 | nM | 7.66 |
| CHEMBL2370477 | — | IC50 | = | 24.6 | nM | 7.61 |
| CHEMBL413010 | — | IC50 | = | 42.4 | nM | 7.37 |
| CHEMBL2370480 | — | IC50 | = | 59.6 | nM | 7.22 |
| CHEMBL2370479 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL410289 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL436717 | — | IC50 | > | 1000.0 | nM | - |