Assay Detail
Binding
CHEMBL754803
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory concentration against rat cerebellar neuronal nitric oxide synthase
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Inhibition of neuronal nitric oxide synthase by 7-methoxyindazole and related substituted indazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.75 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL247378 | 7-NITROINDAZOLE | — | 1 | 6.10 |
| CHEMBL15921 | — | — | 1 | 5.20 |
| CHEMBL392184 | — | — | 1 | 4.55 |
| CHEMBL277525 | — | — | 1 | 4.52 |
| CHEMBL16425 | — | — | 1 | 4.12 |
| CHEMBL274984 | — | — | 1 | 4.00 |
| CHEMBL15739 | — | — | 1 | - |
| CHEMBL16076 | — | — | 1 | - |
| CHEMBL278175 | — | — | 1 | - |
| CHEMBL15932 | — | — | 1 | - |
| CHEMBL277798 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL247378 | 7-NITROINDAZOLE | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL15921 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL392184 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL277525 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL16425 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL274984 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL15739 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL16076 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL278175 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL15932 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL277798 | — | IC50 | > | 100000.0 | nM | - |