Assay Detail
Binding
CHEMBL754918
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Agonist potency using GTP-gamma [35S]- binding assay for opioid receptor kappa 1
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel C-terminus modifications of the Dmt-Tic motif: a new class of dipeptide analogues showing altered pharmacological profiles toward the opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.92 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76573 | — | — | 1 | 8.85 |
| CHEMBL77001 | — | — | 1 | 8.17 |
| CHEMBL310842 | — | — | 1 | 8.16 |
| CHEMBL77804 | — | — | 1 | 7.94 |
| CHEMBL421520 | — | — | 1 | 7.61 |
| CHEMBL80463 | — | — | 1 | 6.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76573 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL77001 | — | EC50 | = | 6.8 | nM | 8.17 |
| CHEMBL310842 | — | EC50 | = | 6.9 | nM | 8.16 |
| CHEMBL77804 | — | EC50 | = | 11.5 | nM | 7.94 |
| CHEMBL421520 | — | EC50 | = | 24.3 | nM | 7.61 |
| CHEMBL80463 | — | EC50 | = | 161.0 | nM | 6.79 |