Assay Detail
Functional
CHEMBL755012
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Activity against opioid receptor in guinea pig ileum longitudinal muscle
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Opioid agonist and antagonist bivalent ligands. The relationship between spacer length and selectivity at multiple opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.73 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3350132 | — | — | 1 | 8.41 |
| CHEMBL3350136 | — | — | 1 | 8.20 |
| CHEMBL3350140 | — | — | 1 | 7.90 |
| CHEMBL3350134 | — | — | 1 | 7.80 |
| CHEMBL3350135 | — | — | 1 | 7.72 |
| CHEMBL3350133 | — | — | 1 | 7.66 |
| CHEMBL3350128 | — | — | 1 | 7.60 |
| CHEMBL3350127 | — | — | 1 | 7.52 |
| CHEMBL3350139 | — | — | 1 | 7.34 |
| CHEMBL607319 | — | — | 1 | 7.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3350132 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL3350136 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL3350140 | — | IC50 | = | 12.6 | nM | 7.90 |
| CHEMBL3350134 | — | IC50 | = | 15.7 | nM | 7.80 |
| CHEMBL3350135 | — | IC50 | = | 19.2 | nM | 7.72 |
| CHEMBL3350133 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3350128 | — | IC50 | = | 25.1 | nM | 7.60 |
| CHEMBL3350127 | — | IC50 | = | 30.2 | nM | 7.52 |
| CHEMBL3350139 | — | IC50 | = | 45.9 | nM | 7.34 |
| CHEMBL607319 | — | IC50 | = | 66.8 | nM | 7.17 |