Assay Detail
Functional
CHEMBL755015
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In vitro opioid inhibitory activity against in guinea pig ileum
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and opioid activity of dermorphin tetrapeptides bearing D-methionine S-oxide at position 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.74 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278789 | DERMORPHIN | — | 1 | 8.85 |
| CHEMBL369354 | — | — | 1 | 8.57 |
| CHEMBL296148 | — | — | 1 | 8.53 |
| CHEMBL171459 | — | — | 1 | 7.87 |
| CHEMBL171887 | — | — | 1 | 7.78 |
| CHEMBL171014 | — | — | 1 | 7.68 |
| CHEMBL171089 | — | — | 1 | 7.66 |
| CHEMBL434111 | — | — | 1 | 7.59 |
| CHEMBL170817 | — | — | 1 | 7.45 |
| CHEMBL355446 | — | — | 1 | 7.34 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 7.19 |
| CHEMBL435267 | — | — | 1 | 7.14 |
| CHEMBL171028 | — | — | 1 | 7.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278789 | DERMORPHIN | IC50 | = | 1.41 | nM | 8.85 |
| CHEMBL369354 | — | IC50 | = | 2.68 | nM | 8.57 |
| CHEMBL296148 | — | IC50 | = | 2.97 | nM | 8.53 |
| CHEMBL171459 | — | IC50 | = | 13.6 | nM | 7.87 |
| CHEMBL171887 | — | IC50 | = | 16.7 | nM | 7.78 |
| CHEMBL171014 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL171089 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL434111 | — | IC50 | = | 25.5 | nM | 7.59 |
| CHEMBL170817 | — | IC50 | = | 35.6 | nM | 7.45 |
| CHEMBL355446 | — | IC50 | = | 45.2 | nM | 7.34 |
| CHEMBL70 | MORPHINE | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL435267 | — | IC50 | = | 72.1 | nM | 7.14 |
| CHEMBL171028 | — | IC50 | = | 97.6 | nM | 7.01 |