Assay Detail
Binding
CHEMBL755096
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In vivo inhibitory potency against neutral endopeptidase by displacement of [3H]HACBOGly binding in mouse kidney
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New dual inhibitors of neutral endopeptidase and angiotensin-converting enzyme: rational design, bioavailability, and pharmacological responses in experimental hypertension.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 8.31 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL273748 | — | — | 1 | 8.89 |
| CHEMBL11495 | — | — | 1 | 8.70 |
| CHEMBL11620 | — | — | 1 | 8.70 |
| CHEMBL11297 | — | — | 1 | 8.70 |
| CHEMBL2051773 | — | — | 1 | 8.70 |
| CHEMBL267766 | — | — | 1 | 8.62 |
| CHEMBL11616 | — | — | 1 | 8.60 |
| CHEMBL11537 | — | — | 1 | 8.51 |
| CHEMBL273898 | — | — | 1 | 8.46 |
| CHEMBL276008 | — | — | 1 | 8.46 |
| CHEMBL11236 | — | — | 1 | 8.40 |
| CHEMBL275690 | — | — | 1 | 8.40 |
| CHEMBL11607 | — | — | 1 | 8.28 |
| CHEMBL273724 | — | — | 1 | 8.23 |
| CHEMBL6915 | — | — | 1 | 8.20 |
| CHEMBL11227 | — | — | 1 | 8.05 |
| CHEMBL416522 | — | — | 1 | 7.96 |
| CHEMBL275980 | — | — | 1 | 7.82 |
| CHEMBL273672 | — | — | 1 | 7.80 |
| CHEMBL11806 | — | — | 1 | 7.80 |
| CHEMBL11344 | — | — | 1 | 7.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL273748 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL11495 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL11620 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL11297 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2051773 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL267766 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL11616 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL11537 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL273898 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL276008 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL11236 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL275690 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL11607 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL273724 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL6915 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL11227 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL416522 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL275980 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL273672 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL11806 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL11344 | — | IC50 | = | 65.0 | nM | 7.19 |