Assay Detail
Binding
CHEMBL755097
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vivo inhibitory potency against neutral endopeptidase by displacement of [3H]HACBOGly binding in mouse kidney
8
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New dual inhibitors of neutral endopeptidase and angiotensin-converting enzyme: rational design, bioavailability, and pharmacological responses in experimental hypertension.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.67 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2052008 | — | — | 4 | 9.15 |
| CHEMBL2052007 | — | — | 3 | 8.80 |
| CHEMBL2051772 | — | — | 1 | 8.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2052008 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL2052007 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL2052008 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL2052008 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL2052008 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL2052007 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL2052007 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL2051772 | — | Ki | = | 5.3 | nM | 8.28 |