Assay Detail
Binding
CHEMBL755122
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In vitro inhibition of rat neuronal nitric oxide synthase
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships of potent, selective inhibitors of neuronal nitric oxide synthase based on the 6-phenyl-2-aminopyridine structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.04 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43678 | — | — | 1 | 7.66 |
| CHEMBL43815 | — | — | 1 | 7.47 |
| CHEMBL40833 | — | — | 1 | 7.40 |
| CHEMBL43240 | — | — | 1 | 7.32 |
| CHEMBL290476 | — | — | 1 | 7.23 |
| CHEMBL42968 | — | — | 1 | 7.10 |
| CHEMBL290875 | — | — | 1 | 7.09 |
| CHEMBL42863 | — | — | 1 | 7.09 |
| CHEMBL39186 | — | — | 1 | 7.06 |
| CHEMBL42969 | — | — | 1 | 7.03 |
| CHEMBL416071 | — | — | 1 | 7.00 |
| CHEMBL40391 | — | — | 1 | 6.90 |
| CHEMBL41343 | — | — | 1 | 6.85 |
| CHEMBL43245 | — | — | 1 | 6.78 |
| CHEMBL38845 | — | — | 1 | 6.76 |
| CHEMBL39005 | — | — | 1 | 6.73 |
| CHEMBL38762 | — | — | 1 | 6.71 |
| CHEMBL41551 | — | — | 1 | 6.51 |
| CHEMBL247378 | 7-NITROINDAZOLE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43678 | — | IC50 | = | 21.75 | nM | 7.66 |
| CHEMBL43815 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL40833 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL43240 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL290476 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL42968 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL290875 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL42863 | — | IC50 | = | 80.5 | nM | 7.09 |
| CHEMBL39186 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL42969 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL416071 | — | IC50 | = | 99.2 | nM | 7.00 |
| CHEMBL40391 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL41343 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL43245 | — | IC50 | = | 167.0 | nM | 6.78 |
| CHEMBL38845 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL39005 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL38762 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL41551 | — | IC50 | = | 306.0 | nM | 6.51 |
| CHEMBL247378 | 7-NITROINDAZOLE | IC50 | = | - | nM | - |