Assay Detail
Binding
CHEMBL755124
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Inhibitory activity against rat neuronal nitric oxide synthase (nNOS)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
A new class of selective and potent inhibitors of neuronal nitric oxide synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.62 | 6.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL87544 | — | — | 1 | 6.97 |
| CHEMBL40391 | — | — | 1 | 6.90 |
| CHEMBL87187 | — | — | 1 | 6.89 |
| CHEMBL86810 | — | — | 1 | 6.71 |
| CHEMBL87529 | — | — | 1 | 6.61 |
| CHEMBL87186 | — | — | 1 | 6.59 |
| CHEMBL247378 | 7-NITROINDAZOLE | — | 1 | 5.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL87544 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL40391 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL87187 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL86810 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL87529 | — | IC50 | = | 247.0 | nM | 6.61 |
| CHEMBL87186 | — | IC50 | = | 256.0 | nM | 6.59 |
| CHEMBL247378 | 7-NITROINDAZOLE | IC50 | = | 2120.0 | nM | 5.67 |