Assay Detail
Binding
CHEMBL755126
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Inhibitory activity against neuronal nitric oxide synthase (nNOS)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Potent and selective conformationally restricted neuronal nitric oxide synthase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.60 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL419740 | — | — | 1 | 7.96 |
| CHEMBL106516 | THIOCITRULLINE | — | 1 | 7.22 |
| CHEMBL161297 | — | — | 1 | 6.19 |
| CHEMBL1169419 | — | — | 1 | 5.02 |
| CHEMBL348164 | — | — | 1 | - |
| CHEMBL2368268 | — | — | 1 | - |
| CHEMBL1169427 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL419740 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL106516 | THIOCITRULLINE | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL161297 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL1169419 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL348164 | — | IC50 | ~ | 100000.0 | nM | - |
| CHEMBL2368268 | — | IC50 | ~ | 100000.0 | nM | - |
| CHEMBL1169427 | — | IC50 | ~ | 100000.0 | nM | - |