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Assay Detail

CHEMBL755131

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against Neuronal Nitric Oxide Synthase (nNOS)
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Nitric oxide synthase 1 (CHEMBL3048)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Aromatic reduced amide bond peptidomimetics as selective inhibitors of neuronal nitric oxide synthase.
Hah JM, Martásek P, Roman LJ, Silverman RB.
J Med Chem (2003) 46 : 1661 -1669
PubMed 12699384 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 25 5.95 7.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL297372 1 7.30
CHEMBL227937 1 6.92
CHEMBL44833 1 6.89
CHEMBL433260 1 6.68
CHEMBL1202106 1 6.35
CHEMBL43937 1 6.26
CHEMBL48070 1 6.13
CHEMBL45243 1 6.12
CHEMBL295429 1 6.05
CHEMBL442999 1 5.87
CHEMBL296102 1 5.87
CHEMBL46913 1 5.86
CHEMBL46974 1 5.80
CHEMBL44964 1 5.80
CHEMBL45113 1 5.78
CHEMBL297096 1 5.70
CHEMBL45441 1 5.69
CHEMBL45021 1 5.69
CHEMBL297095 1 5.66
CHEMBL45132 1 5.66
CHEMBL295848 1 5.66
CHEMBL43997 1 5.64
CHEMBL45119 1 5.54
CHEMBL297207 1 5.26
CHEMBL42093 1 4.69

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL297372 Ki = 50.0 nM 7.30
CHEMBL227937 Ki = 120.0 nM 6.92
CHEMBL44833 Ki = 130.0 nM 6.89
CHEMBL433260 Ki = 210.0 nM 6.68
CHEMBL1202106 Ki = 450.0 nM 6.35
CHEMBL43937 Ki = 550.0 nM 6.26
CHEMBL48070 Ki = 740.0 nM 6.13
CHEMBL45243 Ki = 760.0 nM 6.12
CHEMBL295429 Ki = 890.0 nM 6.05
CHEMBL442999 Ki = 1360.0 nM 5.87
CHEMBL296102 Ki = 1360.0 nM 5.87
CHEMBL46913 Ki = 1370.0 nM 5.86
CHEMBL46974 Ki = 1590.0 nM 5.80
CHEMBL44964 Ki = 1600.0 nM 5.80
CHEMBL45113 Ki = 1660.0 nM 5.78
CHEMBL297096 Ki = 2000.0 nM 5.70
CHEMBL45441 Ki = 2060.0 nM 5.69
CHEMBL45021 Ki = 2060.0 nM 5.69
CHEMBL297095 Ki = 2200.0 nM 5.66
CHEMBL45132 Ki = 2210.0 nM 5.66
CHEMBL295848 Ki = 2210.0 nM 5.66
CHEMBL43997 Ki = 2280.0 nM 5.64
CHEMBL45119 Ki = 2900.0 nM 5.54
CHEMBL297207 Ki = 5550.0 nM 5.26
CHEMBL42093 Ki = 20300.0 nM 4.69