Assay Detail
Binding
CHEMBL755153
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Inhibition of Opioid receptors with [3H]naloxone binding in the absence of NaCl
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of fluoroalkylamine derivatives of narcotic analgesics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.92 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70 | MORPHINE | 4.0 | 1 | 8.00 |
| CHEMBL177893 | — | — | 1 | 7.30 |
| CHEMBL177389 | — | — | 1 | 6.75 |
| CHEMBL607 | MEPERIDINE | 4.0 | 1 | 6.30 |
| CHEMBL178062 | — | — | 1 | 6.00 |
| CHEMBL174811 | — | — | 1 | 5.77 |
| CHEMBL366585 | — | — | 1 | 5.30 |
| CHEMBL368974 | — | — | 1 | 5.00 |
| CHEMBL176525 | — | — | 1 | 4.70 |
| CHEMBL175071 | — | — | 1 | 4.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70 | MORPHINE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL177893 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL177389 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL607 | MEPERIDINE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL178062 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL174811 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL366585 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL368974 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL176525 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL175071 | — | IC50 | = | 85000.0 | nM | 4.07 |