Assay Detail
Binding
CHEMBL755154
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Inhibition of Opioid receptors binding by inhibiting specific [3H]naloxone binding by 50% in the presence of 100 mM NaCl
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of fluoroalkylamine derivatives of narcotic analgesics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.58 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL177893 | — | — | 1 | 7.00 |
| CHEMBL177389 | — | — | 1 | 6.70 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 6.60 |
| CHEMBL178062 | — | — | 1 | 5.94 |
| CHEMBL174811 | — | — | 1 | 5.60 |
| CHEMBL607 | MEPERIDINE | 4.0 | 1 | 4.40 |
| CHEMBL368974 | — | — | 1 | 4.22 |
| CHEMBL176525 | — | — | 1 | 4.19 |
| CHEMBL366585 | — | — | 1 | - |
| CHEMBL175071 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL177893 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL177389 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL70 | MORPHINE | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL178062 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL174811 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL607 | MEPERIDINE | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL368974 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL176525 | — | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL366585 | — | IC50 | = | 120000.0 | nM | - |
| CHEMBL175071 | — | IC50 | = | 110000.0 | nM | - |