Assay Detail
Binding
CHEMBL755200
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In vivo binding affinity was evaluated by measuring the ability to displace [3H]DPDPE radioligand binding from delta opioid receptor in guinea pig brain membranes
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 14-alkoxymorphinans. 11. 3-Hydroxycyprodime and analogues: opioid antagonist profile in comparison to cyprodime.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.37 | 7.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL105665 | — | — | 1 | 7.86 |
| CHEMBL317269 | — | — | 1 | 7.67 |
| CHEMBL317030 | — | — | 1 | 7.59 |
| CHEMBL322195 | — | — | 1 | 7.38 |
| CHEMBL322796 | CYPRODIME | — | 1 | 7.21 |
| CHEMBL104310 | — | — | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL105665 | — | Ki | = | 13.8 | nM | 7.86 |
| CHEMBL317269 | — | Ki | = | 21.4 | nM | 7.67 |
| CHEMBL317030 | — | Ki | = | 25.6 | nM | 7.59 |
| CHEMBL322195 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL322796 | CYPRODIME | Ki | = | 61.1 | nM | 7.21 |
| CHEMBL104310 | — | Ki | = | 334.0 | nM | 6.48 |