Assay Detail
Binding
CHEMBL755203
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Inhibition of binding of [3H]DADLE to Opioid receptor delta 1 in guinea pig membranes
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
2002 Medicinal Chemistry Division Award address: monoamine transporters and opioid receptors. Targets for addiction therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.77 | 7.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19019 | NALTREXONE | 4.0 | 1 | 7.02 |
| CHEMBL52451 | — | — | 1 | 6.85 |
| CHEMBL50594 | — | — | 1 | 6.78 |
| CHEMBL300662 | — | — | 1 | 6.70 |
| CHEMBL51838 | — | — | 1 | 6.49 |
| CHEMBL10986 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19019 | NALTREXONE | Ki | = | 94.9 | nM | 7.02 |
| CHEMBL52451 | — | Ki | = | 142.0 | nM | 6.85 |
| CHEMBL50594 | — | Ki | = | 168.0 | nM | 6.78 |
| CHEMBL300662 | — | Ki | = | 198.0 | nM | 6.70 |
| CHEMBL51838 | — | Ki | = | 322.0 | nM | 6.49 |
| CHEMBL10986 | — | Ki | > | 5700.0 | nM | - |