Assay Detail
Functional
CHEMBL755241
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Cytotoxic activity was measured against human Ovarian carcinoma cell lines
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Panel ovarian (Carcinoma cell lines) |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of 2-acyl analogues of paclitaxel (Taxol).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 8.81 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL333031 | — | — | 1 | 10.30 |
| CHEMBL332916 | — | — | 1 | 10.02 |
| CHEMBL339937 | — | — | 1 | 9.92 |
| CHEMBL337989 | — | — | 1 | 9.92 |
| CHEMBL332915 | — | — | 1 | 9.74 |
| CHEMBL334112 | — | — | 1 | 9.49 |
| CHEMBL441085 | — | — | 1 | 9.49 |
| CHEMBL333647 | — | — | 1 | 9.42 |
| CHEMBL334077 | — | — | 1 | 9.40 |
| CHEMBL122150 | — | — | 1 | 9.17 |
| CHEMBL333226 | — | — | 1 | 9.11 |
| CHEMBL122857 | — | — | 1 | 9.00 |
| CHEMBL410880 | — | — | 1 | 8.89 |
| CHEMBL415835 | — | — | 1 | 8.89 |
| CHEMBL123431 | — | — | 1 | 8.85 |
| CHEMBL331740 | — | — | 1 | 8.85 |
| CHEMBL412803 | — | — | 1 | 8.80 |
| CHEMBL333538 | — | — | 1 | 8.77 |
| CHEMBL339660 | — | — | 1 | 8.51 |
| CHEMBL333526 | — | — | 1 | 8.49 |
| CHEMBL332080 | — | — | 1 | 8.48 |
| CHEMBL123018 | — | — | 1 | 8.48 |
| CHEMBL334075 | — | — | 1 | 8.47 |
| CHEMBL333740 | — | — | 1 | 8.37 |
| CHEMBL331065 | — | — | 1 | 8.32 |
| CHEMBL341501 | — | — | 1 | 8.12 |
| CHEMBL340906 | — | — | 1 | 7.92 |
| CHEMBL124777 | — | — | 1 | 7.89 |
| CHEMBL331998 | — | — | 1 | 7.85 |
| CHEMBL331608 | — | — | 1 | 7.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL333031 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL332916 | — | IC50 | = | 0.095 | nM | 10.02 |
| CHEMBL339937 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL337989 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL332915 | — | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL334112 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL441085 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL333647 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL334077 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL122150 | — | IC50 | = | 0.67 | nM | 9.17 |
| CHEMBL333226 | — | IC50 | = | 0.77 | nM | 9.11 |
| CHEMBL122857 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL410880 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL415835 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL331740 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL123431 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL412803 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL333538 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL339660 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL333526 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL332080 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL123018 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL334075 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL333740 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL331065 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL341501 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL340906 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL124777 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL331998 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL331608 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL408087 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL122465 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL441377 | — | IC50 | > | 48.0 | nM | - |
| CHEMBL341145 | — | IC50 | > | 48.0 | nM | - |