Assay Detail
Binding
CHEMBL755332
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for functional potencies and efficacies at rat Nicotinic acetylcholine receptor alpha4-beta2
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor; alpha4/beta2 (CHEMBL1907596) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Neuronal nicotinic acetylcholine receptors as targets for drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.40 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6623 | EPIBATIDINE | — | 1 | 7.80 |
| CHEMBL335712 | — | — | 1 | 6.43 |
| CHEMBL132966 | RIVANICLINE | 2.0 | 1 | 6.14 |
| CHEMBL274525 | ABT-418 | — | 1 | 5.22 |
| CHEMBL667 | ACETYLCHOLINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6623 | EPIBATIDINE | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL335712 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL132966 | RIVANICLINE | EC50 | = | 730.0 | nM | 6.14 |
| CHEMBL274525 | ABT-418 | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL667 | ACETYLCHOLINE | EC50 | = | 270000.0 | nM | - |