Assay Detail
Binding
CHEMBL755476
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Functional potency for Nicotinic acetylcholine receptor alpha4-beta2 (rat brain)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor; alpha4/beta2 (CHEMBL1907596) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Neuronal nicotinic acetylcholine receptors as targets for drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.08 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6623 | EPIBATIDINE | — | 1 | 7.77 |
| CHEMBL335712 | — | — | 1 | 6.16 |
| CHEMBL3 | NICOTINE | 4.0 | 1 | 5.40 |
| CHEMBL274525 | ABT-418 | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6623 | EPIBATIDINE | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL335712 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3 | NICOTINE | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL274525 | ABT-418 | EC50 | = | 10000.0 | nM | 5.00 |