Assay Detail
Functional
CHEMBL755687
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Antagonistic activity against opioid receptor kappa 1
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design and parallel synthesis of piperidine libraries targeting the nociceptin (N/OFQ) receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.44 | 5.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109598 | — | — | 1 | 5.78 |
| CHEMBL111192 | — | — | 1 | 5.38 |
| CHEMBL113684 | — | — | 1 | 5.37 |
| CHEMBL109563 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109598 | — | Ki | = | 1653.0 | nM | 5.78 |
| CHEMBL111192 | — | Ki | = | 4153.0 | nM | 5.38 |
| CHEMBL113684 | — | Ki | = | 4240.0 | nM | 5.37 |
| CHEMBL109563 | — | Ki | = | 6000.0 | nM | 5.22 |