Assay Detail
Binding
CHEMBL755700
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Binding affinity for opioid receptor type, human Opioid receptor kappa 1 expressed in membrane homogenates of COS-1 or CHO cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | COS-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Probing opioid receptor interactions with azacycloalkane amino acids. Synthesis of a potent and selective ORL1 antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.36 | 7.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL358403 | — | — | 1 | 7.11 |
| CHEMBL266609 | — | — | 1 | 6.72 |
| CHEMBL2371034 | — | — | 1 | 6.55 |
| CHEMBL355931 | — | — | 1 | 6.36 |
| CHEMBL140979 | — | — | 1 | 5.98 |
| CHEMBL356210 | — | — | 1 | 5.96 |
| CHEMBL396460 | NOCICEPTIN | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL358403 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL266609 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL2371034 | — | Ki | = | 282.0 | nM | 6.55 |
| CHEMBL355931 | — | Ki | = | 441.0 | nM | 6.36 |
| CHEMBL140979 | — | Ki | = | 1057.0 | nM | 5.98 |
| CHEMBL356210 | — | Ki | = | 1085.0 | nM | 5.96 |
| CHEMBL396460 | NOCICEPTIN | Ki | = | 1500.0 | nM | 5.82 |