Assay Detail
Functional
CHEMBL755820
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Inhibitory activity against P-selectin using cell-cell assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Development of potent non-carbohydrate imidazole-based small molecule selectin inhibitors with antiinflammatory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.65 | 5.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62853 | — | — | 1 | 5.10 |
| CHEMBL302139 | — | — | 1 | 4.85 |
| CHEMBL293171 | — | — | 1 | 4.01 |
| CHEMBL63898 | — | — | 1 | - |
| CHEMBL292851 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62853 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL302139 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL293171 | — | IC50 | = | 98000.0 | nM | 4.01 |
| CHEMBL63898 | — | IC50 | = | 500000.0 | nM | - |
| CHEMBL292851 | — | IC50 | = | 123000.0 | nM | - |