Assay Detail
Binding
CHEMBL755904
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Binding affinity for NPPF receptor in rat spinal cord membranes using the radioligand [125I]-[Tyr1]NPFF
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Spinal cord |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity study of neuropeptide FF: contribution of N-terminal regions to affinity and activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 8.53 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL414263 | — | — | 1 | 9.80 |
| CHEMBL385751 | — | — | 1 | 9.72 |
| CHEMBL420318 | — | — | 1 | 9.70 |
| CHEMBL269186 | — | — | 1 | 9.70 |
| CHEMBL429731 | — | — | 1 | 9.68 |
| CHEMBL386065 | — | — | 1 | 9.66 |
| CHEMBL331606 | — | — | 1 | 9.37 |
| CHEMBL410577 | — | — | 1 | 9.30 |
| CHEMBL266976 | — | — | 1 | 9.22 |
| CHEMBL406041 | — | — | 1 | 9.00 |
| CHEMBL407343 | — | — | 1 | 8.92 |
| CHEMBL386133 | — | — | 1 | 8.00 |
| CHEMBL326770 | — | — | 1 | 7.81 |
| CHEMBL116185 | — | — | 1 | 7.68 |
| CHEMBL267788 | — | — | 1 | 7.52 |
| CHEMBL115479 | — | — | 1 | 7.48 |
| CHEMBL325517 | — | — | 1 | 7.35 |
| CHEMBL117975 | — | — | 1 | 7.19 |
| CHEMBL325290 | — | — | 1 | 7.03 |
| CHEMBL420508 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL414263 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL385751 | — | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL420318 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL269186 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL429731 | — | Ki | = | 0.21 | nM | 9.68 |
| CHEMBL386065 | — | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL331606 | — | Ki | = | 0.43 | nM | 9.37 |
| CHEMBL410577 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL266976 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL406041 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL407343 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL386133 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL326770 | — | Ki | = | 15.5 | nM | 7.81 |
| CHEMBL116185 | — | Ki | = | 20.9 | nM | 7.68 |
| CHEMBL267788 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL115479 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL325517 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL117975 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL325290 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL420508 | — | Ki | = | 300.0 | nM | 6.52 |