Assay Detail
Binding
CHEMBL756004
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Inhibition of binding of [3H]nicotine to Nicotinic acetylcholine receptor alpha4-beta2 in rat cerebral cortical membranes
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor; alpha4/beta2 (CHEMBL1907596) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
6beta-Acetoxynortropane: a potent muscarinic agonist with apparent selectivity toward M2-receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.76 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3 | NICOTINE | 4.0 | 1 | 9.00 |
| CHEMBL64788 | — | — | 1 | 6.82 |
| CHEMBL294273 | — | — | 1 | 5.82 |
| CHEMBL2115494 | — | — | 1 | 5.40 |
| CHEMBL2114478 | — | — | 1 | 4.62 |
| CHEMBL2115495 | — | — | 1 | 4.50 |
| CHEMBL2114477 | — | — | 1 | 4.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3 | NICOTINE | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL64788 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL294273 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL2115494 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL2114478 | — | Ki | = | 24000.0 | nM | 4.62 |
| CHEMBL2115495 | — | Ki | = | 32000.0 | nM | 4.50 |
| CHEMBL2114477 | — | Ki | = | 64000.0 | nM | 4.19 |