Assay Detail
Binding
CHEMBL756006
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Tested for binding affinity against Nicotinic acetylcholine receptor alpha4-beta2
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor; alpha4/beta2 (CHEMBL1907596) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Synthesis, nicotinic acetylcholine receptor binding affinities, and molecular modeling of constrained epibatidine analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.93 | 10.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6623 | EPIBATIDINE | — | 1 | 10.21 |
| CHEMBL3 | NICOTINE | 4.0 | 1 | 8.00 |
| CHEMBL425135 | — | — | 1 | 7.14 |
| CHEMBL170873 | — | — | 1 | 6.53 |
| CHEMBL367641 | — | — | 1 | 5.16 |
| CHEMBL173610 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6623 | EPIBATIDINE | Ki | = | 0.061 | nM | 10.21 |
| CHEMBL3 | NICOTINE | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL425135 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL170873 | — | Ki | = | 295.0 | nM | 6.53 |
| CHEMBL367641 | — | Ki | = | 6990.0 | nM | 5.16 |
| CHEMBL173610 | — | Ki | = | 29200.0 | nM | 4.54 |