Assay Detail
Binding
CHEMBL756018
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In vitro binding affinity against Opioid receptors from bovine caudate nucleus determined in presence of [3H]- bremazocine (0.5 nM)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Conjugate addition ligands of opioid antagonists. Methacrylate esters and ethers of 6 alpha- and 6 beta-naltrexol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.34 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL350384 | BREMAZOCINE | 2.0 | 1 | 9.30 |
| CHEMBL166355 | — | — | 1 | 8.62 |
| CHEMBL163704 | — | — | 1 | 8.30 |
| CHEMBL610531 | — | — | 1 | 8.22 |
| CHEMBL76023 | — | — | 1 | 7.92 |
| CHEMBL3084322 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL350384 | BREMAZOCINE | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL166355 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL163704 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL610531 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL76023 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3084322 | — | IC50 | = | 20.0 | nM | 7.70 |