Assay Detail
Functional
CHEMBL756021
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Opioid receptors antagonist activity in smooth-muscle tissue of guinea pig ileum (GPI)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Design and synthesis of highly potent and selective cyclic dynorphin A analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.89 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL443068 | — | — | 1 | 8.89 |
| CHEMBL415330 | — | — | 1 | 8.77 |
| CHEMBL410616 | — | — | 1 | 8.76 |
| CHEMBL384250 | — | — | 1 | 8.64 |
| CHEMBL411557 | DYNORPHIN A (1-17) | — | 1 | 8.60 |
| CHEMBL216640 | — | — | 1 | 8.12 |
| CHEMBL385759 | — | — | 1 | 5.97 |
| CHEMBL265824 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL443068 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL415330 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL410616 | — | IC50 | = | 1.75 | nM | 8.76 |
| CHEMBL384250 | — | IC50 | = | 2.27 | nM | 8.64 |
| CHEMBL411557 | DYNORPHIN A (1-17) | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL216640 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL385759 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL265824 | — | IC50 | = | 4406.0 | nM | 5.36 |