Assay Detail
Binding
CHEMBL756059
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Agonist potency using GTP-gamma [35S]- binding assay for delta-opioid receptor
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel C-terminus modifications of the Dmt-Tic motif: a new class of dipeptide analogues showing altered pharmacological profiles toward the opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 8.72 | 9.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL421520 | — | — | 1 | 9.49 |
| CHEMBL310842 | — | — | 1 | 9.19 |
| CHEMBL80463 | — | — | 1 | 9.12 |
| CHEMBL77001 | — | — | 1 | 9.04 |
| CHEMBL76089 | — | — | 1 | 9.01 |
| CHEMBL80823 | — | — | 1 | 8.82 |
| CHEMBL75802 | — | — | 1 | 8.77 |
| CHEMBL76573 | — | — | 1 | 8.55 |
| CHEMBL317956 | DELTORPHIN C | — | 1 | 8.33 |
| CHEMBL309783 | — | — | 1 | 8.24 |
| CHEMBL76846 | — | — | 1 | 7.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL421520 | — | EC50 | = | 0.32 | nM | 9.49 |
| CHEMBL310842 | — | EC50 | = | 0.65 | nM | 9.19 |
| CHEMBL80463 | — | EC50 | = | 0.75 | nM | 9.12 |
| CHEMBL77001 | — | EC50 | = | 0.92 | nM | 9.04 |
| CHEMBL76089 | — | EC50 | = | 0.97 | nM | 9.01 |
| CHEMBL80823 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL75802 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL76573 | — | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL317956 | DELTORPHIN C | EC50 | = | 4.71 | nM | 8.33 |
| CHEMBL309783 | — | EC50 | = | 5.7 | nM | 8.24 |
| CHEMBL76846 | — | EC50 | = | 49.4 | nM | 7.31 |