Assay Detail
Binding
CHEMBL756125
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Binding affinity towards nicotinic acetylcholine receptor alpha4-beta2 from rat brain homogenates
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor; alpha4/beta2 (CHEMBL1907589) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
3-(4-Aminobutyn-1-yl)pyridines: binding at alpha 4 beta 2 nicotinic cholinergic receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 7.19 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL345732 | — | — | 1 | 9.30 |
| CHEMBL3 | NICOTINE | 4.0 | 1 | 8.68 |
| CHEMBL61616 | — | — | 1 | 7.68 |
| CHEMBL57912 | — | — | 1 | 7.66 |
| CHEMBL60792 | — | — | 1 | 7.55 |
| CHEMBL148489 | N-(3-PYRIDYLMETHYL)PYRROLIDINE | — | 1 | 7.52 |
| CHEMBL112221 | — | — | 1 | 7.46 |
| CHEMBL348693 | — | — | 1 | 6.96 |
| CHEMBL54860 | — | — | 1 | 6.95 |
| CHEMBL347558 | — | — | 1 | 6.81 |
| CHEMBL328429 | — | — | 1 | 6.67 |
| CHEMBL151817 | — | — | 1 | 6.33 |
| CHEMBL150893 | — | — | 1 | 6.29 |
| CHEMBL331904 | — | — | 1 | 6.27 |
| CHEMBL150948 | — | — | 1 | 5.75 |
| CHEMBL147446 | — | — | 1 | - |
| CHEMBL151983 | — | — | 1 | - |
| CHEMBL357101 | — | — | 1 | - |
| CHEMBL146956 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL345732 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL3 | NICOTINE | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL61616 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL57912 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL60792 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL148489 | N-(3-PYRIDYLMETHYL)PYRROLIDINE | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL112221 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL348693 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL54860 | — | Ki | = | 113.0 | nM | 6.95 |
| CHEMBL347558 | — | Ki | = | 154.0 | nM | 6.81 |
| CHEMBL328429 | — | Ki | = | 212.0 | nM | 6.67 |
| CHEMBL151817 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL150893 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL331904 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL150948 | — | Ki | = | 1770.0 | nM | 5.75 |
| CHEMBL147446 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL151983 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL357101 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL146956 | — | Ki | = | - | nM | - |