Assay Detail
Binding
CHEMBL756222
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Binding affinity against Opioid receptor delta 1 using [3H]DADLE as radioligand in guinea pig brain
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis, biological evaluation, and quantitative receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodiazepines as novel tifluadom-like ligands with high affinity and selectivity for kappa-opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.59 | 6.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL127969 | — | — | 1 | 6.98 |
| CHEMBL169703 | TIFLUADOM | 2.0 | 1 | 6.82 |
| CHEMBL127463 | — | — | 1 | 6.56 |
| CHEMBL127968 | — | — | 1 | 6.00 |
| CHEMBL341529 | — | — | 1 | - |
| CHEMBL124015 | — | — | 1 | - |
| CHEMBL126282 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL127969 | — | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL169703 | TIFLUADOM | Ki | = | 153.0 | nM | 6.82 |
| CHEMBL127463 | — | Ki | = | 275.0 | nM | 6.56 |
| CHEMBL127968 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL341529 | — | Ki | > | 300.0 | nM | - |
| CHEMBL124015 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL126282 | — | Ki | > | 1000.0 | nM | - |