Assay Detail
Binding
CHEMBL756263
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Compound was tested for inhibition of [3H]NE binding to norepinephrine transporter HEK cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Bivalent biogenic amine reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.46 | 8.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL306208 | — | — | 1 | 8.09 |
| CHEMBL303266 | — | — | 1 | 6.58 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 6.42 |
| CHEMBL307314 | — | — | 1 | 6.31 |
| CHEMBL432727 | — | — | 1 | 5.73 |
| CHEMBL407803 | — | — | 1 | 5.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL306208 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL303266 | — | IC50 | = | 266.0 | nM | 6.58 |
| CHEMBL370805 | COCAINE | IC50 | = | 385.0 | nM | 6.42 |
| CHEMBL307314 | — | IC50 | = | 487.0 | nM | 6.31 |
| CHEMBL432727 | — | IC50 | = | 1846.0 | nM | 5.73 |
| CHEMBL407803 | — | IC50 | = | 2258.0 | nM | 5.65 |